UDK 2011-12 Unreal Frontend refuses to launch on clean install

[Zofii]

Issue: executing UnrealFrontend.exe starts a process but never runs or opens the program

History: installed a copy of 2011-12 beta on my computer, have never had a previous installation, UDK game and editor load and run perfectly fine, frontend appears to load but just creates the process and never actually opens. Program runs perfectly fine on my primary computer. (And no I can't launch it over network and a copied folder duplicates the same issue)

Specs:

OS: Windows Vista 64 Home Premium
CPU: Intel Pentium Dual Core E2180 2.0 GHZ
GPU: ASUS EAH AMD 4550
RAM: 2GB
HDD: 57gb free of 220

[DougClayton4231]

You might have some registry corruption. Try reinstalling Windows to see if that fixes the problem.

[Zofii]

have never had a previous installation,

I'm not reinstalling windows.
Also there is no such thing as a "registry corruption"

[Zofii]

Issue solved, the latest drivers for my Wacom Intuos4 Pentablet were preventing UFE from launching. Ending the process for the drivers (and also uninstalling them) allow me to run UFE perfectly fine.